ти полека со дрогите сам си знаеш коа ти е доста... :pos2::pos2:
шала на страна дад да научиме нешто
постот беше саркастичен...
Жалфија дивинорум
Long term
Differing studies suggest no overall consensus so far with regard to the long-term effects of
Salvia divinorum on mood. It is well-established that some k-opioid agonists can cause
dysphoria in humans,
[63] and research using rats in forced-swim tests (where they're forced to swim in a narrow cylinder from which they cannot escape) has been used to suggest that
Salvia divinorum may have "depressive-like" effects.
[64] However, a report has been published detailing an individual case of
Salvia divinorum use as self-medicated treatment for depression,
[65] and Baggott's survey of 500 people with firsthand experience of salvia found that 25.8% of respondents reported improved mood and "antidepressant-like effects" lasting 24 hours or longer. Only 4.4% reported persisting (24 hours or more) negative effects (most often anxiety) on at least one occasion.
[58]
It has been suggested that the long-term effects of
Salvia use may include déjà vu.
[66] On the question of addiction the Baggott survey found little evidence of dependence in its survey population. 0.6% percent of respondents reported feeling addicted to or dependent on salvia at some point, and 1.2% reported strong cravings. About this the researchers said "there were too few of these individuals to interpret their reports with any confidence".
Most users report no hangover or negative after-effects the next day. This is consistent with the apparent low toxicity of
Salvia indicated by research conducted at the University of Nebraska.
[43]
LSD
Potential risks of LSD use
LSD is generally considered nontoxic, although it may temporarily impair the ability to make sensible judgments and understand common dangers, thus making the user more susceptible to accidents and personal injury. There is also some indication that LSD may trigger a
dissociative fugue state in individuals who are taking certain classes of
antidepressants such as
lithium salts and
tricyclics. In such a state, the user has an impulse to wander, and may not be aware of his or her actions, which can lead to physical injury. Anonymous anecdotal reports have attributed seizures and one death to the combination of LSD with lithium.
[46] SSRIs are believed to interact more benignly, with a tendency to noticeably reduce LSD's subjective effects.
[47] Similar and perhaps greater effects have also been reported with
MAOIs.
[46]
As Albert Hofmann reports in
LSD – My Problem Child, the early pharmacological testing Sandoz performed on the compound (before he ever discovered its psychoactive properties) indicated that LSD has a pronounced effect upon the mammalian
uterus. Sandoz's testing showed that LSD can stimulate uterine contractions with efficacy comparable to
ergobasine, the active uterotonic component of the
ergot fungus (Hofmann's work on ergot derivatives also produced a modified form of
ergobasine which became a widely accepted medication used in
obstetrics, under the trade name
Methergine). Therefore, LSD use by pregnant women could be dangerous and is
contraindicated.
[4]
Initial studies in the 1960s and 1970s raised concerns that LSD might produce genetic damage
[48] or developmental abnormalities in fetuses. However, these initial reports were based on
in vitro studies or were poorly controlled and have not been substantiated. In studies of
chromosomal changes in human users and in monkeys, the balance of evidence suggests no increase in chromosomal damage. For example, studies were conducted with people who had been given LSD in a clinical setting.
[48] White blood cells from these people were examined for visible chromosomal abnormalities. Overall, there appeared to be no lasting changes. Several studies have been conducted using illicit LSD users and provide a less clear picture. Interpretation of this data is generally complicated by factors such as the unknown chemical composition of street LSD, concurrent use of other
psychoactive drugs, and diseases such as
hepatitis in the sampled populations. It seems possible that the small number of genetic abnormalities reported in users of street LSD is either coincidental or related to factors other than a toxic effect of pure LSD.
[48]
DMT
Side effects
When DMT is vaporized, the
vapor produced is often felt to be very harsh on the lungs.
According to a "Dose-response study of
N,N-dimethyltryptamine in humans" by
Rick Strassman, "Dimethyltryptamine dose slightly elevated blood pressure, heart rate, pupil diameter, and rectal temperature, in addition to elevating blood concentrations of beta-
endorphin,
corticotropin,
cortisol, and
prolactin.
Growth hormone blood levels rose equally in response to all doses of DMT, and
melatonin levels were unaffected."
[18]
_________________________
Ако ги прочитате “лошите ефекти“ внимателно, ке дознаете дека пушењето цигари е поштетно.
