First, we must be clear how the effect of nicotine shows itself. The effect of nicotine shows itself above all in the activity of the heart. Through nicotine, an increased, stronger activity of the heart is called forth. The heart is not a pump, however, but only indicates what goes on in the body: the heart beats faster when the blood circulates faster. Nicotine therefore actually affects the blood circulation, animating it. One must therefore be clear that through the introduction of nicotine into the human body, the blood circulation is stimulated. This, in turn, calls forth a stronger activity of the heart.
Now, this whole process in the human organism must be traced. You must be clear that everything occurring in the human organism is actually strictly regulated. One of the most important points regarding the human organism, for example, is the fact that the pulse rate of the adult is 72 beats a minute, and this holds true even into old age.
By comparison, as I have mentioned to you before, man takes about 18 breaths a minute. When you multiply 18 by 4, you get 72. This means that on the average the blood substance pulses four times as quickly through the body as does the breath. Of course, these are average figures; they differ slightly in each human being. The fact that this ratio varies in people accounts for the differences between them, but on the average it is 1:4; that is, the blood circulation is four times stronger than that of the breathing rhythm.
If I now introduce nicotine into the human organism, I can do it for two reasons—first, because of a strong liking for tobacco, and second, as a remedy. Every substance that is poisonous is also a remedy. Everything, one can say, is both poisonous and healing. If, for example, you drink several buckets of water, they naturally have a poisonous effect, whereas the proper amount is a means of sustenance, and when it is introduced in unusually small amounts, it can even be a remedy. As a matter of fact, water is generally a potent remedy when certain methods are employed. It can therefore be said that even the most commonplace substances can be poisons as well as remedies. This is why the effect that a given substance has on the human organism must be known.
If I introduce tobacco into the human organism, it first stimulates the blood circulation. The blood becomes more active, circulating more vigorously. Breathing, however, is not stimulated to the same degree by tobacco; the breathing rhythm remains the same. The blood circulation is therefore no longer synchronized with the breathing. If man were to introduce nicotine into his body, he would need a blood circulation different from the one he ordinarily has.
Let us say, for example, that there were a person whose system was adjusted to the exact average of 18 breaths and 72 pulse beats (there aren't any such persons, but let's assume there were one). Now, nicotine causes his pulse rate to increase to, let us say, 76 beats. The correct ratio between the pulse and the respiration thus is altered. The result is that the blood doesn't receive enough oxygen, since a certain amount is supposed to be absorbed into the blood with each pulse beat. The consequence of nicotine poisoning, therefore, is that the blood demands too much oxygen. The breathing process does not supply enough oxygen, and a slight shortness of breath occurs. This shortness of breath is, of course, so negligible that it escapes notice; after all, as I have told you, the human body can take a lot of abuse. Nevertheless, the use of nicotine always calls forth a definite, very slight shortness of breath. This slight shortness of breath causes with each breath a feeling of anxiety. Every shortness of breath causes a feeling of anxiety. It is easier to control a normal sensation of anxiety than this terribly slight anxiety, of which one is completely unconscious. When something like anxiety, fear, or shock remains unnoticed, it is a direct source of illness.
Such a source of illness is constantly present in a person who is a heavy smoker because, without realizing it, he is always filled with a certain anxiety. Now, you know that if you suffer from anxiety, your heart pumps more quickly. This leads you to realize that the heart of a person who constantly poisons himself with nicotine continuously beats somewhat too fast. When it beats too quickly, however, the heart thickens, just as the muscle of the upper arm, the biceps, grows thicker when it is constantly strained. Under some circumstances, this is not so bad, as long as the inner tissue doesn't tear. If the heart muscle—it is also a muscle—becomes too thick from over-exertion, however, it exerts pressure on all the other organs with the result, as a rule, that beginning from the heart the blood circulation becomes disturbed. The circulation of the blood cannot be initiated by the heart, but it can be disturbed when the heart is thickened
