Пред 4-5 години од замунда симнав еден документарец чиешто име го заборавив и којшто го немам веќе. Ако некој го пронајде нека ми прати линк до него на пп. Се зборуваше за Thalidomide(
http://en.wikipedia.org/wiki/Thalidomide) и неговата новонајдена нова употреба. Еве некои материјали од англиската википедија, немам време да ги преведувам, ниту пак по струка сум доктор, па само ќе ги постирам овде она што мислам дека е позначајно да се забележе:
Cancer treatment
In 1994 Harvard Professor Robert D'Amato at Boston Children's Hospital discovered that thalidomide was a potent inhibitor of new blood vessel growth (angiogenesis), which is required for tumor growth.[50] He then showed in a rabbit cancer model that thalidomide suppressed tumor growth in animals.[51] Interestingly, he also found that a subset of anti-inflammatory drugs, such as sulindac and dexamethasone, had moderate anti-angiogenic activity. When these anti-inflammatory anti-angiogenic drugs were combined with thalidomide they increased both thalidomide's anti-angiogenic and anti-tumor activity. Based on these discoveries, numerous cancer clinical trials for thalidomide were initiated with and without dexamethasone.
...
Thalidomide appears to inhibit disease progression in multiple myeloma by several mechanisms:
- Inhibition of angiogenesis in the bone marrow, which is needed for myeloma cell proliferation.
- Inhibition of the production of interleukin-6 (IL‑6), which is a growth factor for the proliferation of myeloma cells[60]
- Activation of apoptotic pathways through caspase 8-mediated cell death[60]
- At the mitochondrial level, thalidomide results in induction of c-jun terminal kinase (JNK).[60]
- Activation of T cells to produce IL‑2, thereby altering the amount and function of natural killer cells (NK cells), thus augmenting the activity of NK‑dependent cytotoxicity[60]
All
physicians prescribing and patients receiving thalidomide must go through the STEPS process to ensure that no more children are born with birth defects traceable to the medication. Celgene has sponsored numerous clinical trials with analogues to thalidomide, such as
lenalidomide, that are substantially more powerful and have fewer side effects — except for greater
myelosuppression.
[61]
Thalidomide is also being investigated for treating
prostate cancer,
[62] glioblastoma,
[63] lymphoma,
[64] arachnoiditis,
Behçet's disease, and
Crohn's disease.
[65] In a small trial, Australian researchers found thalidomide caused a doubling of the number of
T cells in patients, allowing the patients' own
immune system to attack cancer cells.
[66]
Откога се откри за новата примена на овој лек, се разработи и аналогна посилна верзија, наречена Lenalidomide, еве го краткиот опис од англиска википедија:
Lenalidomide (pron.: /lɛnəˈlɪdɵmaɪd/) (Revlimid) is a derivative of thalidomide introduced in 2004.
It was initially intended as a treatment for multiple myeloma, for which thalidomide is an accepted therapeutic treatment. Lenalidomide has also shown efficacy in the class of hematological disorders known as myelodysplastic syndromes (MDS). Lenalidomide has significantly improved overall survival in myeloma (which generally carries a poor prognosis), although toxicity remains an issue for users. [1] It costs $163,381 per year for the average patient.[2]
Овие лекарста имаат против сериозни индикации и не би требало да се земаат без лекарска согласност.
Исто така пред некој месец гледав на Натионал Географик документарна емисија за човечките гени, а во којашто еден дел вклучуваше експериментална генетска терапија на заболен од некаков неизлечлив вид на рак, којашто за жал заврши неуспешно а во еден момент изгледаше дека целосно ќе успее да го победи ракот. Ако некој ја најде и таа емисија, да ми прати линк на пп.
И некое инфо за мелатонин, ова не е лек за ракот, исто така ако го земате консултирајте се со лекар, но има некои интересни информации за него:
Many biological effects of melatonin are produced through activation of melatonin receptors,[5] while others are due to its role as a pervasive and powerful antioxidant,[6] with a particular role in the protection of nuclear and mitochondrial DNA.[7]
...
Besides its function as synchronizer of the biological clock, melatonin also exerts a powerful antioxidant activity. ... This antioxidant is a direct scavenger of radical oxygen and nitrogen species including: OH, O2−, and NO. ... Unlike other antioxidants, melatonin does not undergo redox cycling, the ability of a molecule to undergo reduction and oxidation repeatedly. Redox cycling may allow other antioxidants (such as vitamin C) to act as pro-oxidants, counterintuitively promoting free radical formation. ... Melatonin, on the other hand, once oxidized, cannot be reduced to its former state because it forms several stable end-products upon reacting with free radicals. Therefore, it has been referred to as a terminal (or suicidal) antioxidant.
In animal models, melatonin has been demonstrated to prevent the damage to DNA by some carcinogens, stopping the mechanism by which they cause cancer.
...
This suggests that melatonin is involved in the clonal expansion of antigen-stimulated human T lymphocytes.
Јас за оваа тематика којашто не ми е струка толку сум запознат и толку можам да помогнам. Што се однесува до останатите
алтернативни лекови, признавам само доколку се знае механизмот на дејство и има докажана ефикасност во научно истражување.
