Lester Freamon
A man of focus, commitment, sheer will...
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- 14 јануари 2015
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Инаку еве едно интересно истражување што го сретнав пред неколку денови, кој е заинтересиран може да го прочита.
Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control
Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control
In conclusion, we show that long-term dietary BCAA manipula-
tion influences healthspan and lifespan in mice by regulating food
intake via a mechanism that involves their interaction with key non-
BCAAs, including Trp and Thr. Dietary amino acid imbalance influ-
ences central and peripheral appetite signalling via Trp-mediated
5-HT depletion, resulting in hyperphagia, obesity, hepatosteatosis
and reduced lifespan. These metabolic and lifespan costs occur in
the absence of hepatic mTOR activation and are reversed by pre-
venting hyperphagia using 20% calorie restriction or pair-feeding.
The results indicate that the adverse effects on imbalanced high
BCAA:non-BCAA diets are secondary to hyperphagia rather than
any intrinsic BCAA toxicity. Food intake, health and lifespan are
titrated against both the macronutrient composition, quantity and
quality of dietary protein